Cellulitis progressing to sepsis — spreading erythema/warmth with fever, hypotension, or new confusion in a lymphedematous limb — escalate/transfer on the sepsis pathway.

Necrotizing infection — crepitus, dusky skin, pain out of proportion, rapid spread — emergency transfer.

Suspected DVT — unilateral worsening edema with warmth/tenderness — escalate (route to Peripheral Vascular/Anticoagulation).

Compression-related compromise — new pain, numbness, or perfusion change under compression — remove and reassess.