Line-associated bloodstream infection / sepsis — fever, rigors, or hypotension in a resident with a central line — escalate/transfer; do not use the suspected line.

Air embolism or catheter embolus — sudden dyspnea, chest pain, or neurologic change with a central line — emergency positioning/protocol and transfer.

Uncontrolled bleeding or dislodgement of a central line — apply pressure, protect the site, and escalate/transfer.

Infiltration/extravasation of a vesicant — stop the infusion, follow the extravasation protocol, and notify the provider.